Systems biology of vaccination for seasonal influenza in humans
Identifieur interne : 001591 ( Main/Exploration ); précédent : 001590; suivant : 001592Systems biology of vaccination for seasonal influenza in humans
Auteurs : Helder I. Nakaya [États-Unis] ; Jens Wrammert [États-Unis] ; Eva K. Lee [États-Unis] ; Luigi Racioppi [États-Unis, Italie] ; Stephanie Marie-Kunze [États-Unis] ; W Nicholas Haining [États-Unis] ; Anthony R. Means [Italie] ; Sudhir P. Kasturi [États-Unis] ; Nooruddin Khan [États-Unis] ; Gui-Mei Li [États-Unis] ; Megan Mccausland [États-Unis] ; Vibhu Kanchan [États-Unis] ; Kenneth E. Kokko [États-Unis] ; Shuzhao Li [États-Unis] ; Rivka Elbein [États-Unis] ; Aneesh K. Mehta [États-Unis] ; Alan Aderem [États-Unis] ; Kanta Subbarao [États-Unis] ; Rafi Ahmed [États-Unis] ; Bali Pulendran [États-Unis]Source :
- Nature Immunology [ 1529-2908 ] ; 2011-08.
Abstract
Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons. We studied healthy adults vaccinated with trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). TIV induced higher antibody titers and more plasmablasts than LAIV did. In subjects vaccinated with TIV, early molecular signatures correlated with and could be used to accurately predict later antibody titers in two independent trials. Notably, expression of the kinase CaMKIV at day 3 was inversely correlated with later antibody titers. Vaccination of CaMKIV-deficient mice with TIV induced enhanced antigen-specific antibody titers, which demonstrated an unappreciated role for CaMKIV in the regulation of antibody responses. Thus, systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines.
Identifying molecular predictors of effective vaccination is an important clinical and technical goal. Pulendran and colleagues use a systems biology approach to study human responses to vaccination against influenza and determine the correlates of immunogenicity.
Url:
DOI: 10.1038/ni.2067
Affiliations:
- Italie, États-Unis
- Caroline du Nord, Géorgie (États-Unis), Maryland, Massachusetts, Washington (État)
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Nakaya</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Emory Vaccine Center, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Yerkes National Primate Research Center, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Wrammert, Jens" sort="Wrammert, Jens" uniqKey="Wrammert J" first="Jens" last="Wrammert">Jens Wrammert</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Emory Vaccine Center, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lee, Eva K" sort="Lee, Eva K" uniqKey="Lee E" first="Eva K" last="Lee">Eva K. 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Mehta</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Aderem, Alan" sort="Aderem, Alan" uniqKey="Aderem A" first="Alan" last="Aderem">Alan Aderem</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Institute for Systems Biology, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Emory Vaccine Center, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Pulendran, Bali" sort="Pulendran, Bali" uniqKey="Pulendran B" first="Bali" last="Pulendran">Bali Pulendran</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Emory Vaccine Center, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Yerkes National Primate Research Center, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pathology, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature Immunology</title><idno type="ISSN">1529-2908</idno><idno type="eISSN">1529-2916</idno><imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher><date when="2011-08">2011-08</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="786">786</biblScope><biblScope unit="page" to="795">795</biblScope><date type="Copyright" when="2011">2011</date></imprint><idno type="ISSN">1529-2908</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1529-2908</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons. We studied healthy adults vaccinated with trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). TIV induced higher antibody titers and more plasmablasts than LAIV did. In subjects vaccinated with TIV, early molecular signatures correlated with and could be used to accurately predict later antibody titers in two independent trials. Notably, expression of the kinase CaMKIV at day 3 was inversely correlated with later antibody titers. Vaccination of CaMKIV-deficient mice with TIV induced enhanced antigen-specific antibody titers, which demonstrated an unappreciated role for CaMKIV in the regulation of antibody responses. Thus, systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines.</div><div type="abstract" xml:lang="eng">Identifying molecular predictors of effective vaccination is an important clinical and technical goal. Pulendran and colleagues use a systems biology approach to study human responses to vaccination against influenza and determine the correlates of immunogenicity.</div></front></TEI><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Géorgie (États-Unis)</li><li>Maryland</li><li>Massachusetts</li><li>Washington (État)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Nakaya, Helder I" sort="Nakaya, Helder I" uniqKey="Nakaya H" first="Helder I" last="Nakaya">Helder I. Nakaya</name></region><name sortKey="Aderem, Alan" sort="Aderem, Alan" uniqKey="Aderem A" first="Alan" last="Aderem">Alan Aderem</name><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name><name sortKey="Elbein, Rivka" sort="Elbein, Rivka" uniqKey="Elbein R" first="Rivka" last="Elbein">Rivka Elbein</name><name sortKey="Haining, W Nicholas" sort="Haining, W Nicholas" uniqKey="Haining W" first="W Nicholas" last="Haining">W Nicholas Haining</name><name sortKey="Kanchan, Vibhu" sort="Kanchan, Vibhu" uniqKey="Kanchan V" first="Vibhu" last="Kanchan">Vibhu Kanchan</name><name sortKey="Kanchan, Vibhu" sort="Kanchan, Vibhu" uniqKey="Kanchan V" first="Vibhu" last="Kanchan">Vibhu Kanchan</name><name sortKey="Kasturi, Sudhir P" sort="Kasturi, Sudhir P" uniqKey="Kasturi S" first="Sudhir P" last="Kasturi">Sudhir P. Kasturi</name><name sortKey="Kasturi, Sudhir P" sort="Kasturi, Sudhir P" uniqKey="Kasturi S" first="Sudhir P" last="Kasturi">Sudhir P. Kasturi</name><name sortKey="Khan, Nooruddin" sort="Khan, Nooruddin" uniqKey="Khan N" first="Nooruddin" last="Khan">Nooruddin Khan</name><name sortKey="Khan, Nooruddin" sort="Khan, Nooruddin" uniqKey="Khan N" first="Nooruddin" last="Khan">Nooruddin Khan</name><name sortKey="Kokko, Kenneth E" sort="Kokko, Kenneth E" uniqKey="Kokko K" first="Kenneth E" last="Kokko">Kenneth E. Kokko</name><name sortKey="Lee, Eva K" sort="Lee, Eva K" uniqKey="Lee E" first="Eva K" last="Lee">Eva K. Lee</name><name sortKey="Li, Gui Mei" sort="Li, Gui Mei" uniqKey="Li G" first="Gui-Mei" last="Li">Gui-Mei Li</name><name sortKey="Li, Gui Mei" sort="Li, Gui Mei" uniqKey="Li G" first="Gui-Mei" last="Li">Gui-Mei Li</name><name sortKey="Li, Shuzhao" sort="Li, Shuzhao" uniqKey="Li S" first="Shuzhao" last="Li">Shuzhao Li</name><name sortKey="Li, Shuzhao" sort="Li, Shuzhao" uniqKey="Li S" first="Shuzhao" last="Li">Shuzhao Li</name><name sortKey="Marie Kunze, Stephanie" sort="Marie Kunze, Stephanie" uniqKey="Marie Kunze S" first="Stephanie" last="Marie-Kunze">Stephanie Marie-Kunze</name><name sortKey="Marie Kunze, Stephanie" sort="Marie Kunze, Stephanie" uniqKey="Marie Kunze S" first="Stephanie" last="Marie-Kunze">Stephanie Marie-Kunze</name><name sortKey="Mccausland, Megan" sort="Mccausland, Megan" uniqKey="Mccausland M" first="Megan" last="Mccausland">Megan Mccausland</name><name sortKey="Mccausland, Megan" sort="Mccausland, Megan" uniqKey="Mccausland M" first="Megan" last="Mccausland">Megan Mccausland</name><name sortKey="Mehta, Aneesh K" sort="Mehta, Aneesh K" uniqKey="Mehta A" first="Aneesh K" last="Mehta">Aneesh K. Mehta</name><name sortKey="Nakaya, Helder I" sort="Nakaya, Helder I" uniqKey="Nakaya H" first="Helder I" last="Nakaya">Helder I. Nakaya</name><name sortKey="Pulendran, Bali" sort="Pulendran, Bali" uniqKey="Pulendran B" first="Bali" last="Pulendran">Bali Pulendran</name><name sortKey="Pulendran, Bali" sort="Pulendran, Bali" uniqKey="Pulendran B" first="Bali" last="Pulendran">Bali Pulendran</name><name sortKey="Pulendran, Bali" sort="Pulendran, Bali" uniqKey="Pulendran B" first="Bali" last="Pulendran">Bali Pulendran</name><name sortKey="Pulendran, Bali" sort="Pulendran, Bali" uniqKey="Pulendran B" first="Bali" last="Pulendran">Bali Pulendran</name><name sortKey="Racioppi, Luigi" sort="Racioppi, Luigi" uniqKey="Racioppi L" first="Luigi" last="Racioppi">Luigi Racioppi</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Wrammert, Jens" sort="Wrammert, Jens" uniqKey="Wrammert J" first="Jens" last="Wrammert">Jens Wrammert</name><name sortKey="Wrammert, Jens" sort="Wrammert, Jens" uniqKey="Wrammert J" first="Jens" last="Wrammert">Jens Wrammert</name></country><country name="Italie"><noRegion><name sortKey="Racioppi, Luigi" sort="Racioppi, Luigi" uniqKey="Racioppi L" first="Luigi" last="Racioppi">Luigi Racioppi</name></noRegion><name sortKey="Means, Anthony R" sort="Means, Anthony R" uniqKey="Means A" first="Anthony R" last="Means">Anthony R. 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